Botulinum neurotoxin formulations: overcoming the confusion [Corrigendum]
نویسندگان
چکیده
منابع مشابه
Botulinum neurotoxin: the ugly duckling.
This review presents a brief account of the most significant biological effects and clinical applications of botulinum neurotoxins, in a way comprehensive even for casual readers who are not familiar with the subject. The most toxic known substances in botulinum neurotoxins are polypeptides naturally synthesized by bacteria of the genus Clostridium. These polypeptides inhibit acetylcholine rele...
متن کاملOn Botulinum Neurotoxin Variability
The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric view of these neurotoxins as human botulism-causing a...
متن کاملRegulation of Botulinum Neurotoxin Expression
Botulinal neurotoxin continues to be a concern in food safety. The molecular biology of botulinal neurotoxin gene expression in Clostridium botuli-num is poorly understood. In this study, the transcriptional and translational kinetics of expression of type A botulinal neurotoxin by C. botulinum type A strains Hall A, 62A, and NCTC 2916 were determined during 96 hours of growth. Strains were gro...
متن کاملThe potency testing of botulinum neurotoxin products.
I should like to strongly endorse the article by Andy Pickett,1 published in the September issue of ATLA, in which he criticises the lack of published information relating to a new in vitro method developed by Allergan Inc., which has received regulatory approval as a replacement for the LD50 mouse bioassay for the potency testing of a botulinum neurotoxin (BoNT) series of products. Clearly, th...
متن کاملThe pretherapeutic history of botulinum neurotoxin
Unintended intoxication with botulinum neurotoxin (botulism) occurs only rarely, but its high fatality rate makes it a great concern for the general public and the medical community. In the USA, an average of 110 cases of botulism are reported each year. Of these, approximately 25% are food borne, 72% are infant botulism and the rest are wound botulism. Outbreaks of food-borne botulism involvin...
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ژورنال
عنوان ژورنال: Clinical, Cosmetic and Investigational Dermatology
سال: 2018
ISSN: 1178-7015
DOI: 10.2147/ccid.s176565